Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake

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Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake

The melanocortin system is one of the most important neuronal pathways involved in the regulation of food intake and is probably the best characterized. Agouti-related peptide (AgRP) and proopiomelanocortin (POMC) expressing neurons located in the arcuate nucleus of the hypothalamus are the key elements of this system. These two neuronal populations are sensitive to circulating molecules and re...

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Role of Hypothalamic Melanocortin System in Adaptation of Food Intake to Food Protein Increase in Mice

The hypothalamic melanocortin system--the melanocortin receptor of type 4 (MC4R) and its ligands: α-melanin-stimulating hormone (α-MSH, agonist, inducing hypophagia), and agouti-related protein (AgRP, antagonist, inducing hyperphagia)--is considered to play a central role in the control of food intake. We tested its implication in the mediation of the hunger-curbing effects of protein-enriched ...

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The melanocortin system as a central integrator of direct and indirect controls of food intake.

THE NEURAL CONTROL OF FOOD INTAKE and body weight is a complex function in which cognitive and emotional variables, as well as long-term signals of metabolic status and fuel storage, are integrated with short-term signals related to individual meals. Several years ago, Smith (20) proposed a useful classification of the myriad signals that influence the amount of food eaten during individual mea...

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ژورنال

عنوان ژورنال: Frontiers in Endocrinology

سال: 2015

ISSN: 1664-2392

DOI: 10.3389/fendo.2015.00143